Skip to content

Your source for high quality CBD
products approved by pharmacists!

Posts by The Hemp Health

Full Spectrum vs. CBD

When you’re looking for a CBD product to purchase, you may see some products labeled differently. Full Spectrum Hemp Extract, THC-Free, Aerial Plant Parts, and CBD are just a few of the descriptions you might find on a bottle of CBD. Let’s take a closer look at some of these terms, and what they mean for you when you’re looking for a CBD product.

Full Spectrum Hemp Extract

Over 100 different phytocannabinoids have been isolated from the Cannabis plant. Cannabidiol, or CBD, is the predominant cannabinoid in industrial hemp products. Legally, these industrial hemp products – like the ones sold by The Hemp Health – cannot contain more than 0.3% tetrahydrocannabinol (THC). Along with CBD, hemp contains an abundance of compounds including terpenes, plant sterols, chlorophyll, and many others.

We believe that using a full-spectrum hemp extract will allow your body to take full advantage of all the cannabinoids and other compounds that are found in hemp. It is believed that these compounds work synergistically, which is sometimes referred to as the “Hemptourage Effect”.

A 2015 study showed that when pure CBD (that is, the single molecule, without any other compounds) was administered to a group of mice, the benefit resembled a bell-curve. This means that at very low doses and very high doses, there was little to no benefit, and at the “sweet spot” somewhere in the middle, the optimal dose was found. To contrast, when the mice were given whole plant CBD-rich extract, there was a dose-dependent response curve. This means that the benefit was realized at lower doses, and that a larger benefit was realized at higher doses.

While we don’t believe that more is always better when it comes to CBD, we appreciate the findings of that study, which support our recommendations to use whole plant or full-spectrum hemp extract.

THC-free Hemp Products

Some patients have concerns about even the small (<0.3%) amount of THC that is found in agricultural hemp products. This may be for a number of reasons, but the most common concern is that there is a possibility of a positive result on a urine drug screen. While there is a 1-2% chance of a positive result with using full spectrum hemp products, we have many patients who are using full spectrum hemp products from The Hemp Health and have not had a positive urine drug screen.

That being said, we understand that patients who may be randomly drug tested as a condition of their employment (such as healthcare workers, transportation workers subject to DOT physicals, law enforcement officers, firefighters, EMTs/paramedics, etc) may prefer a different product. We do sell products that are THC-free. That is, the THC has been removed as part of the processing of the product, so you’re still getting the benefit of CBD, but may not be experiencing the optimal benefit that you would be getting with the full spectrum extract.

Liquid Dosing Recommendations

We recommend starting with a sublingual oil so you can start low and titrate your dose up. We also recommend that you commit to 2 to 4 months for your desired health benefits.  The key to success with your hemp product is patience and working your dose up until you get relief

One of the most important things to be very clear on is that there is no ‘across the board’ dose for CBD Oil. The very best way to find the amount of CBD that will be effective for you is to begin low 5-10 mg at bedtime. After 3 days, increase to twice daily and slowly work your dose up every 3 days. Once you get the desired results, stay at that dose. You may always increase or decrease your dose to get your desired health results. Certain conditions take a longer time and a higher dose. We have seen people get no benefit for weeks then get relief on week 7 or 8. 

It is also good to recognize that the needs of your body are not exactly the same each day. Most people find an average daily dose that is helpful but they also acknowledge that on some days, the dose needs to be increased a bit due to variables such as changes in the weather, pain from ‘over doing it’ a bit, or a stressful event.

Almost everyone who is considering CBD asks, “Why can’t I just start with the highest dose capsule?” Many folks are put off by the oral spray or sublingual (under the tongue) oil format… but it is an important tool for you and here’s why:

The oral oils allow you to begin at the modest dose of 3 to 12 mg of CBD and increase very gradually over a 2 to 4 month trial. This slow introduction greatly increases the chance that you will experience as much receptor activation as possible. If you begin at higher doses prior to ‘nudging’ your receptors you may be wasting some of the CBD. There is no advantage to starting at the highest dose.

Once you have established your “foundation” dose, then you can decide which format will best serve your needs. Capsules & soft gels are available in a variety of doses. We believe that placing the oil under your tongue provides the best absorption. We even have ointments if you have targeted issues with one joint.

There are also those who find that a capsule in the morning and a few sprays or drops in the afternoon provides their custom dose. Remember, everyone is different. In the end, you are using the introduction of CBD to slowly wake up your body, setting the stage for best results, and finding the optimal dose for your targeted wellness issues.

Introducing… The Dosing Schedule!

Health ConditionStarting Dose/
Target Dose*
Approx. Time to Relief
Stress/Anxiety3-6mg at bedtime,
up to 12-25mg per day
About 1 week
Joint Pain6-12mg at bedtime,
up to 25-50mg per day
2-6 weeks
Back Pain6-12mg at bedtime,
up to 30-75mg per day
Up to 8 weeks
Crohn’s/Colitis6-12mg at bedtime,
up to 30-75mg per day
8-12 weeks
Parkinson’s/MS6mg at bedtime, up to
12-25mg per day
6-8 weeks
Fibromyalgia,
auto-immune
diseases
6-12mg at bedtime,
up to 30-100mg per day
Up to 3 months

Increase by 1/4 to 1/2 dropper every 3 to 7 days until you’re feeling the relief you’re looking for. At that point, you can hold at that dose and don’t need to increase any further. Some people increase their dose for a few days as needed (for example, before a stressful event or greater physical exertion), and then back down to their baseline daily dose.

*Target dose is typically split twice daily. For example, a target dose of 50mg per day could be split into 25mg twice daily for a total of 50mg.

Another approach to dosing

Once you choose your starting dose, use that at bedtime for 3 days. After 3 days then use that same dose in the morning and evening for 3 days. 
Day 1-3 Dose x bedtime
Day 4-6 Dose x twice daily
Day 7-9 Dose x morning , 2x(starting dose x2) at bedtime
Day10-12  Dose 2x (twice the starting dose) twice daily
You may continue going up every 3 days or you may increase at a slower rate after the first two weeks. Whenever you get the desired relief you may stay at that dose.

Rushing through the dosing schedule does not provide any additional benefit, and may cause you to waste the CBD oil that you’ve invested in.

The first thing you will notice with CBD is you will sleep better in the first few days and then anxiety will decrease in the first 2 weeks. Pain and inflammation will take anywhere from 2-8 weeks. Autoimmune diseases take longer for results, and can take 2-6 months for best results our patients tell us.

Pay attention to your body. Maybe there are certain areas of your body that really hurt every morning when you wake, or prevent you from falling asleep at night, or flare up when you engage in a specific activity (reaching up to get something from the kitchen cabinet, swinging your leg up when you get onto your bike). Pay attention to these as you move through your first days using CBD. If at any point you feel that some of this pain that you have become used to is changing or reducing, make a note of this on the back of your chart. If at some point you realize that you are just feeling a bit better in general, make a note of this.

You can ‘pause’ your trial at any point and REPEAT that same dose for a few days to determine if that is a good daily dose for you. (i.e., on day 10 you really feel a reduction in pain… rather than moving onto day 11 you are going to do the Day 10 dose for 2 or 3 days. Maybe this is your dose? Has your pain gone from a level of 10 to a level of 6? Or less? Is your stress response easing up? Anxiety diminishing? Sleep improving?

If you have experienced a reduction in pain or anxiety but would like to see if you can get an even better result, then go ahead and proceed with increasing the dose until desired results

Once you have determined your best dose, then you can choose which format is best for you.

SPECIAL NOTES

  1. The dosing trial is meant to continue until you get relief. CBD takes 4-12 weeks to see the results you desire depending on what you are using it for. The key is patience and working your dose up every 3-7 days until desired effect. 
  2. CBD & your prescription medications: With rare exception (e.g., blood-thinning medications ), there is no conflict with medications during the  dosing trial. If you find that CBD is a good tool for you and you are interested in ongoing use, then it is wise to speak to your prescribing physician. CBD makes use of some of the same pathways in the body that many common medications use. Over the long run this “competition” for pathways may lessen or increase the effectiveness of a medication. Your physician can monitor this at your check-ups and make dosing adjustments if needed. Do not make these adjustments on your own. If you are taking a specialized medication or have an acute health condition with related medications, please speak to us about this prior to beginning your trial.

Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disease, meaning that over time, progressive degeneration (deteriorating) of the nervous system leads to various movement disorders or difficulties. Hallmark signs of Parkinson’s Disease are tremors or rigidity (stiffness). Symptoms typically start gradually, sometimes starting with a barely noticeable tremor in just one hand. Over time, patients may lose expression in their face, their arms may not swing as they walk, and their speech may become slurred or soft. These symptoms may worsen over time, and will likely result in difficulties performing activities of daily living (ADL). In the early stages of Parkinson’s disease, your face may show little or no expression. Your arms may not swing when you walk. Your speech may become soft or slurred. Parkinson’s disease symptoms worsen as your condition progresses over time.

Unfortunately, Parkinson’s disease has no cure. Doctors can prescribe medications to improve symptoms or slow the progression of the disease. Preliminary research is beginning to understand the role that the endocannabinoid system (ECS) may play in the management of symptoms in Parkinson’s disease. CBD may improve motor symptoms of Parkinson’s such as tremors or rigidity, and may also provide some neuroprotective effects as well that may slow the progression of disease.

Research articles:

Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection

Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial

Multiple Sclerosis

Multiple sclerosis, or MS, occurs when the body’s immune system “eats away” at the protective covering of nerves (called the myelin sheath). This resulting nerve damage disrupts communication between the brain and the body. Multiple sclerosis can cause many different symptoms, including vision loss, pain, fatigue, and impaired coordination. The symptoms, severity, and duration can vary from person to person. Some people may be symptom free most of their lives, while others can have severe chronic symptoms that never go away. Physical therapy and medications that suppress the immune system can help with symptoms and slow disease progression, but there is no cure. Unfortunately, medications that weaken the immune system come with the potential for serious side effects. 

Because of this, some patients have turned to CBD oil to help with symptoms of multiple sclerosis. While CBD is not a replacement for the mainstays of treatment, preliminary research and case reports have shown some benefit when CBD is added to the regimen. Patients report that CBD helps with the muscle spasticity symptoms of MS.

One study showed that “…objective improvement in mobility and patients’ opinion of an improvement in pain suggest that cannabinoids might be clinically useful.” 

Anxiety Relief through CBD

Anxiety is a normal part of life. Most of us experience anxiety intermittently as certain situations arise. Medical treatment is usually not necessary for occasional anxiety.

However, anxiety that is persistent, seemingly uncontrollable, or overwhelming may be cause for concern. Excessive, irrational dreading of everyday situations can be disabling. Anxiety that interferes with daily activities should be discussed with your doctor, as you may have an anxiety disorder. According to the Anxiety and Depression Association of America, anxiety disorders are real, serious medical conditions – just as real and serious as physical disorders such as heart disease or diabetes. Anxiety disorders are the most common and pervasive mental disorders in the United States.

During any given year, almost 40 million Americans are estimated to experience some type of anxiety disorder. Despite this staggering number, only about one-third of these patients actually receive treatment. 

Preliminary research and case reports have shown that CBD has anxiolytic (anti-anxiety) and anti-depressant-like properties. In addition, patients that experience sleep disruptions may use CBD oil to support healthier sleep patterns. Patients that are struggling with anxiety or insomnia should discuss with their psychiatrist about including CBD oil in their therapy regimen.

We have found that doses on the lower end of the dosing spectrum tend to work better for patients using CBD oil for anxiety or insomnia.

For further information, you may wish to peruse these research reports and case studies:

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol – A Chemical Compound of Cannabis sativa

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

Topical vs Oral Applications of CBD

We often receive questions about whether to apply hemp topically or take it orally. Topical hemp works great for patients with pain or inflammation in a single joint, such as a knee, elbow, or foot. The topical formulations generally do not penetrate deep enough to be used for chronic back pain, although we do have a patient who uses it with heat, and she says it helps dampen the pain. The topical pens seem to work well for headaches if you apply it on your temple. Patients with neuropathy, especially in the feet, use the cream or ointment with some benefit, but we generally recommend to add oral CBD with the topical, so the two can work synergistically. There are transdermal creams that absorb well enough to elicit blood levels similar to that of oral formulations. These transdermal creams are a great choice for people who do not tolerate the oral formulations. One drawback of using the topical formulations is that they tend to be a little more expensive than their oral counterparts. 

My personal bias is that hemp is so healthy for a multitude of symptoms. It helps balance out your own endocannabinoid system. It helps balance your immune system which in turn works on chronic inflammation.  It is a great antioxidant, neuroprotectant, anxiety reducer, pain reducer, and auto-immune disease modifier. This begs the question, why would you not take it internally? There are so many benefits to taking it internally, that many of our patients plan to use it long term for a continued healthy lifestyle.

CBD 101

We think that it’s important for you to understand how CBD works in your body. While much of this information is in “laymen’s” terms, it should give you a sound grasp on the concepts of CBD and how it could work for you.

The brands of CBD that we sell were selected based on their quality of sourcing, processing, chemical analysis policies, and third party independent analytical testing. These companies have been pioneers in the hemp industry, and they continue to support scientific case studies and the legislative movement to make CBD available nationwide to consumers. Do not get overwhelmed by this information, and feel free to call us with any questions! We’re here for you!

WHAT EXACTLY IS CBD, and how can it help my body?

Your body produces endocannabinoids (bear with me here!), these are “messengers” that are isolated from the brain and peripheral tissues that communicate using cannabinoid receptors located throughout your body.

In order for these messengers to convey information, you must produce a healthy supply and the receptors must be healthy and active. Unfortunately, through the natural course of aging and due to many outside factors that cause stress to our operating systems, our production of endocannabinoids may no longer be sufficient.

This is where phytocannabinoids come into play. Cannabidiol (CBD) is a phytocannabinoid whose molecules very closely resemble those of your endocannabinoids. CBD can often step in and fill the gap in your messaging system, creating the potential for better reduction in pain & inflammation, a stronger immune balance, and for some a better response to and recovery from stress and anxiety.

Think of a giant puzzle with some missing pieces. Your brain can pretty much tell what that puzzle picture is… but still, with those missing pieces the message isn’t clear. CBD is able to sharpen the picture and fill in the gaps. As the CBD is slowly introduced to your system, the receptors begin to recognize that activity and the presence of the chemical that they are designed to receive and “wake up”. Once there is some reactivation of the receptors, your body has an increased ability for “cross system” communication… in other words, get more accurate messages to the correct locations.

Finding Your Dose

We recommend starting with a sublingual oil so you can start low and titrate your dose up. We also recommend that you commit to 2 to 4 months for your desired health benefits.  The key to success with your hemp product is patience and working your dose up until you get relief

One of the most important things to be very clear on is that there is no ‘across the board’ dose for  CBD Oil. The very best way to find the amount of CBD that will be effective for you is to begin low 5-10 mg at bedtime . After 3 days go to twice daily and slowly work your dose up every 3 days . Once you get the desired results stay at that dose. You may always increase or decrease your dose to get your desired health results. Certain conditions take a longer time and a higher dose. We have seen people get no benefit for weeks then get relief on week 7 or 8. 

It is also good to recognize that the needs of your body are not exactly the same each day. Most people find an average daily dose that is helpful but they also acknowledge that on some days, the dose needs to be increased a bit due to variables such as changes in the weather, pain from ‘over doing it’ a bit, or a stressful event.

Almost everyone who is considering CBD asks, “Why can’t I just start with the highest dose capsule?” Many folks are put off by the oral spray or sublingual (under the tongue) oil format… but it is an important tool for you and here’s why:

The spray or oil applications allow you to begin at the modest dose of 3 to 6 mg of CBD and increase very gradually over a 2 to 4 month trial. This slow introduction greatly increases the chance that you will experience as much receptor activation as possible. If you begin at higher doses prior to ‘nudging’ your receptors you may be wasting some of the CBD. There is no advantage to starting at the highest dose.

Once you have established your “foundation” dose, then you can decide which format will best serve your needs. Capsules & soft gels are available in a variety of doses. We believe that placing the oil under your tongue provides the best absorption. We even have ointments if you have targeted issues with one joint.

There are also those who find that a capsule in the morning and a few sprays or drops in the afternoon provides their custom dose. Remember, everyone is different. In the end, you are using the introduction of CBD to slowly wake up your body, setting the stage for best results, and finding the optimal dose for your targeted wellness issues.

Introducing… The Dosing Schedule!

Once you chose your starting dose ( Dose x) use that at bedtime for 3 days. Days 4-6 use the starting dose twice daily.
Example
Day 1-3 Dose x at bed for 3 days
Day 4-6 Dose x twice daily
Day7-9 Dose x am, Dose 2x(twice the starting dose)
Day 10-12 Dose 2x(twice the strating dose) twice daily
You may continue increasing every 3-7 days after first 2 weeks until you get the desired effect. 
Rushing through the dosing schedule does not provide any additional benefit, and may cause you to waste the CBD oil that you’ve invested in.

Pay attention to your body. Maybe there are certain areas of your body that really hurt every morning when you wake, or prevent you from falling asleep at night, or flare up when you engage in a specific activity (reaching up to get something from the kitchen cabinet, swinging your leg up when you get onto your bike). Pay attention to these as you move through your first days using CBD. If at any point you feel that some of this pain that you have become used to is changing or reducing, make a note of this on the back of your chart. If at some point you realize that you are just feeling a bit better in general, make a note of this.

You can ‘pause’ your trial at any point and REPEAT that same dose for a few days to determine if that is a good daily dose for you. (i.e., on day 10 you really feel a reduction in pain… rather than moving onto day 11 you are going to do the Day 10 dose for 2 or 3 days. Maybe this is your dose? Has your pain gone from a level of 10 to a level of 6? Or less? Is your stress response easing up? Anxiety diminishing? Sleep improving?

If you have experienced a reduction in pain or anxiety but would like to see if you can get an even better result, then go ahead and proceed with increasing the dose until desired results

Once you have determined your best dose, then you can choose which format is best for you.

SPECIAL NOTES

  1. The dosing trial is meant to continue until you get relief. CBD takes 4-12 weeks to see the results you desire depending on what you are using it for. The key is patience and working your dose up every 3 days until desired effect. 
  2. CBD & your prescription medications: With rare exception (e.g., blood-thinning medications ), there is no conflict with medications during the  dosing trial. If you find that CBD is a good tool for you and you are interested in ongoing use, then it is wise to speak to your prescribing physician. CBD makes use of some of the same pathways in the body that many common medications use. Over the long run this “competition” for pathways may lessen or increase the effectiveness of a medication. Your physician can monitor this at your check-ups and make dosing adjustments if needed. Do not make these adjustments on your own. If you are taking a specialized medication or have an acute health condition with related medications, please speak to us about this prior to beginning your trial.

What Do Bioavailability and Sublingual Mean For Me?

Bioavailability explained

There are many reasons why we may want to take CBD-rich hemp extracts, whether it be to improve symptoms of a chronic condition, or just for general health maintenance and well-being. In all cases, we want to get as much out of every dose as possible. For this, the bioavailability of CBD and other cannabinoids must be maximized. Bioavailability means how much of a substance is able to enter the bloodstream unchanged.

Maximizing Bioavailability

So how can we maximize bioavailability? When a drug is given intravenously (IV), the bioavailability is 100%, because it gets past barriers such as the intestinal wall and liver metabolism. When a medicine is taken orally, it may not be absorbed through the intestines because of insufficient time. Being highly water soluble or not dissolving enough are two reasons why a drug may take longer to be absorbed. Poor digestion, binding to other substances, or use by the intestinal bacteria are other reasons why it may not be absorbed. After a nutrient, medicine, or something else is absorbed from your gut into the bloodstream, it passes through the liver. In the liver, a portion of an absorbed substance is metabolized (changed), which makes the affected substance more water soluble. This is to prepare it for the next time it enters the liver, where it is readied for excretion.

All about sublingual administration

So what does sublingual mean, and what does it have to do with bioavailability? Sublingual administration of medicines is when it is designed for absorption under the tongue, not in the stomach and intestines like food. “Sub” means “under”, and “lingual” means “relating to the tongue.” As this also means direct transfer into the blood, it avoids issues relating to the intestinal barrier. These include inability to be absorbed, interaction with other nutrients or drugs, or use by normal intestinal bacteria. It also avoids being directly shuttled to the liver and resulting changes to its structure.

Of course, CBD is also vulnerable to issues that can affect intestinal absorption, as well as being processed by the liver. Because of this, a small study in 2003 set out to find any differences in the bioavailability of CBD and THC when taken in different ways. The dosage methods tested were oral, oro-pharyngeal (throat), buccal (inside of the cheek) and sublingual. When CBD was taken sublingually, the half-life was 86 minutes, while oral use had a half-life of 65 minutes. The term “half-life” means the time taken for half of the tested substance to be removed from the body.

Another measure of bioavailability, known as “area under the curve” (AUC), also showed a superior score for sublingual CBD. The two AUC scores for sublingual use were 408.53 and 427.33. However, the scores for oral use were 345.68 and 362.04. The AUC measurement shows the total exposure of the body to a medicine once it is given. Therefore, a higher AUC can mean a greater potential to be effective.

Liposomes offer increased bioavailability

Liposomal hemp extracts may be even more bioavailable, as the type of fat that the hemp extract would be surrounded by can enable easy, efficient absorption. While more human trials are needed, sublingual CBD and CBD-rich hemp extracts may be better than taking a regular capsule, as it could bypass many obstacles between the cannabinoids and their intended destination.

Further reading:

https://www.merckmanuals.com/professional/clinical-pharmacology/pharmacokinetics/drug-bioavailability

http://www.pharmtech.com/considerations-developing-sublingual-tablets-overview

Oral Cannabis Benefits

Crohn’s Disease

Crohn’s Disease is a chronic inflammatory bowel disease (IBD) that affects the lining of the digestive tract. Another form of chronic inflammatory bowel disease is ulcerative colitis (UC). Both of these diseases can be extremely debilitating, and can affect the patient’s quality of life. Both of these forms of IBD are classified as autoimmune diseases. This means the body’s immune system essentially attacks itself, causing severe inflammation (in this case, in the GI tract). There is currently no cure for inflammatory bowel disease; treatments are geared towards the resolution or minimization of symptoms. Many prescription drug treatments work by weakening the patient’s immune system to reduce flare ups. Unfortunately, these medications can cause side effects that include infections that can be life threatening, since the body’s immune system is being weakened and can’t fight off these infections.

Instead of weakening the immune system, we have seen great success in patients who use CBD oil to help with symptoms of Crohn’s Disease and ulcerative colitis. CBD has great anti-inflammatory and properties, and is able to exert these anti-inflammatory effects in the GI tract when CBD oil is taken by mouth. Patients report reduction in the frequency of flare-ups, less severe flare-ups, fewer stools per day, and improvements in weight gain. Because CBD is also used to improve mental health, patients with Crohn’s Disease also report reduction in depression symptoms associated with their disease.

“I’ve been using CBD oil for over 5 months now. I’ve been diagnosed with Crohn’s for 7 years and only been in remission for less than 3 years on and off. The main treatment is pharmaceutical drugs usually mixed in with steroid treatment when things get real bad. I’ve had not only little success in treating it with the drugs, but the side effects have been just as bad as the Crohn’s symptoms. The more research I did, the more I started to come across CBD oil in treatment options for Crohn’s. Within 2 weeks, I noticed significant inflammation reduction in my GI system which has led to higher quality of life and fewer symptoms from Crohn’s/UC that were really limiting my day-to-day life. I have been basically able to return to a “normal life”, increased sleep, no pain, and solid digestion patterns. I would certainly recommend this product for anyone dealing with these issues.” -B.H.

Talk to us today to see if CBD oil is right for your Crohn’s Disease or Ulcerative Colitis symptoms. We look forward to helping you live healthier through hemp!

Cannabis Alleviates Symptoms Of Crohn’s Disease

Cannabis Finds Its Way into Treatment of Crohn’s Disease

Cannabis Induces a Clinical Response in Patients With Crohn’s Disease – A Prospective Placebo – Controlled Study

Science of CBD

How Science Supports the Benefits

Whole-plant extract contains cannabinoids, which are chemical compounds within the hemp plant that have been reported, both from anecdotal evidence and pre-clinical studies, to offer relief from a multitude of ailments.

Structurally, cannabinoids resemble endocannabinoids which are compounds our bodies naturally produce to balance and control communication between cells as well as promote cellular health.

Preliminary research suggests that many unpleasant symptoms and diseases occur when a deficiency or other problem impacts the endocannabinoid system (eCS). The primary function of the eCS is to maintain homeostasis. It allows cells to communicate with other cells and their external environment and facilitates cells doing whatever is necessary to be healthy. Cannabinoids have been shown to bind to a number of different receptor sites in the brain and body, and have different effects based on which receptors they bind to and how they interact.

The most well-known receptor interactions are those between cannabinoids and CB1 and CB2 receptors, which are the primary receptors in the eCS. CB1 receptors are concentrated in the brain and central nervous system while CB2 receptors are concentrated in the peripheral immune system.

CB1 receptors regulate:

  • Learning and memory
  • Neuronal development and synaptic plasticity
  • Reward and addiction
  • Pain
  • Neuroinflammation and degeneration
  • Metabolism and food intake
  • Bone mass
  • Cardiovascular effects

CB2 receptors regulate:

  • Allergic and autoimmune inflammatory disease
  • Osteoporosis
  • Neurodegenerative disease
  • Ischemic injury from stroke or heart attack
  • Chronic pain
  • Hepatic injury and disease
  • Alcohol and nicotine addiction
  • Weight gain
  • Stress response

Receptors function at a base level of activity. When cannabinoids, like those found in activated hemp extract, bind to these receptors, the receptors either do more or less of what they were doing.  For example, inflammation is a common cause of discomfort. When cannabinoids interact with CB2 receptors, some studies indicate that it reduces the inflammatory response. It has also been reported that activated hemp extract interacts with CB2 receptors on cancer cells by recognizing these cells are not healthy and initiating apoptosis (a sequence of biochemical reactions that results in cell death).

With an increasing understanding of the effects of cannabinoids, patients can now tailor their cannabinoid therapy regimen to the type of relief they need.

Learn More About Hemp

Whole-plant hemp extract is a combination of the most prevalent therapeutic, activated compounds in the hemp plant. It offers numerous benefits without altering your mental state. For decades, medical professionals and the general public overlooked hemp extract because other plant remedies took center stage.

Now, the medicinal potential of hemp extract has made its way to mainstream audiences. Pre-clinical trials over the past four decades have found that cannabinoids, like those found in hemp extract, show potential to be a natural anti-inflammatory, antioxidant, neuroprotectant, antidepressant, along with many other benefits.

0